RapamycinFungusV1, Main, Exploration, bibRecord, 001874

Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression.

Identifieur interne : 001874 ( Main/Exploration ); précédent : 001873; suivant : 001875

Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression.

Auteurs : Rosa M. Marion [États-Unis] ; Aviv Regev ; Eran Segal ; Yoseph Barash ; Daphne Koller ; Nir Friedman ; Erin K. O'Shea

Source :

Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2004.

RBID : pubmed:15353587

Descripteurs français

English descriptors

KwdEn :
- Cyclic AMP-Dependent Protein Kinases (metabolism), DNA-Binding Proteins (genetics), DNA-Binding Proteins (metabolism), Gene Expression Regulation, Fungal (MeSH), Genes, Fungal (MeSH), Models, Biological (MeSH), Oligonucleotide Array Sequence Analysis (MeSH), Phosphatidylinositol 3-Kinases (genetics), Phosphatidylinositol 3-Kinases (metabolism), Phosphotransferases (Alcohol Group Acceptor) (genetics), Phosphotransferases (Alcohol Group Acceptor) (metabolism), Promoter Regions, Genetic (MeSH), Ribosomal Proteins (genetics), Saccharomyces cerevisiae (drug effects), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae (metabolism), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), Signal Transduction (MeSH), Sirolimus (pharmacology), Subcellular Fractions (metabolism).
MESH :
- chemical , genetics : DNA-Binding Proteins, Phosphatidylinositol 3-Kinases, Phosphotransferases (Alcohol Group Acceptor), Ribosomal Proteins, Saccharomyces cerevisiae Proteins.
- chemical , metabolism : Cyclic AMP-Dependent Protein Kinases, DNA-Binding Proteins, Phosphatidylinositol 3-Kinases, Phosphotransferases (Alcohol Group Acceptor), Saccharomyces cerevisiae Proteins.
- drug effects : Saccharomyces cerevisiae.
- genetics : Saccharomyces cerevisiae.
- metabolism : Saccharomyces cerevisiae, Subcellular Fractions.
- chemical , pharmacology : Sirolimus.
- Gene Expression Regulation, Fungal, Genes, Fungal, Models, Biological, Oligonucleotide Array Sequence Analysis, Promoter Regions, Genetic, Signal Transduction.

Abstract

Yeast cells modulate their protein synthesis capacity in response to physiological needs through the transcriptional control of ribosomal protein (RP) genes. Here we demonstrate that the transcription factor Sfp1, previously shown to play a role in the control of cell size, regulates RP gene expression in response to nutrients and stress. Under optimal growth conditions, Sfp1 is localized to the nucleus, bound to the promoters of RP genes, and helps promote RP gene expression. In response to inhibition of target of rapamycin (TOR) signaling, stress, or changes in nutrient availability, Sfp1 is released from RP gene promoters and leaves the nucleus, and RP gene transcription is down-regulated. Additionally, cells lacking Sfp1 fail to appropriately modulate RP gene expression in response to environmental cues. We conclude that Sfp1 integrates information from nutrient- and stress-responsive signaling pathways to help control RP gene expression.

DOI: 10.1073/pnas.0405353101
PubMed: 15353587
PubMed Central: PMC521938

Affiliations:

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<term>Gene Expression Regulation, Fungal (MeSH)</term>
<term>Genes, Fungal (MeSH)</term>
<term>Models, Biological (MeSH)</term>
<term>Oligonucleotide Array Sequence Analysis (MeSH)</term>
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<term>Phosphatidylinositol 3-Kinases (metabolism)</term>
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<term>Saccharomyces cerevisiae (metabolism)</term>
<term>Saccharomyces cerevisiae Proteins (genetics)</term>
<term>Saccharomyces cerevisiae Proteins (metabolism)</term>
<term>Signal Transduction (MeSH)</term>
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<term>Modèles biologiques (MeSH)</term>
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<term>Phosphatidylinositol 3-kinases (métabolisme)</term>
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<term>Saccharomyces cerevisiae (génétique)</term>
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<front><div type="abstract" xml:lang="en">Yeast cells modulate their protein synthesis capacity in response to physiological needs through the transcriptional control of ribosomal protein (RP) genes. Here we demonstrate that the transcription factor Sfp1, previously shown to play a role in the control of cell size, regulates RP gene expression in response to nutrients and stress. Under optimal growth conditions, Sfp1 is localized to the nucleus, bound to the promoters of RP genes, and helps promote RP gene expression. In response to inhibition of target of rapamycin (TOR) signaling, stress, or changes in nutrient availability, Sfp1 is released from RP gene promoters and leaves the nucleus, and RP gene transcription is down-regulated. Additionally, cells lacking Sfp1 fail to appropriately modulate RP gene expression in response to environmental cues. We conclude that Sfp1 integrates information from nutrient- and stress-responsive signaling pathways to help control RP gene expression.</div>
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<Abstract><AbstractText>Yeast cells modulate their protein synthesis capacity in response to physiological needs through the transcriptional control of ribosomal protein (RP) genes. Here we demonstrate that the transcription factor Sfp1, previously shown to play a role in the control of cell size, regulates RP gene expression in response to nutrients and stress. Under optimal growth conditions, Sfp1 is localized to the nucleus, bound to the promoters of RP genes, and helps promote RP gene expression. In response to inhibition of target of rapamycin (TOR) signaling, stress, or changes in nutrient availability, Sfp1 is released from RP gene promoters and leaves the nucleus, and RP gene transcription is down-regulated. Additionally, cells lacking Sfp1 fail to appropriately modulate RP gene expression in response to environmental cues. We conclude that Sfp1 integrates information from nutrient- and stress-responsive signaling pathways to help control RP gene expression.</AbstractText>
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	Serveur d'exploration sur la rapamycine et les champignons
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Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression.

Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression.

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